Open access publisher BioMed Central, UK, is publishing a thematic series of articles describing the construction, content and current use of Ensembl's resources, to mark the 10th anniversary of the Ensembl project’s launch. The Ensembl project is a joint venture between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute.
The last 15 years has reportedly seen an explosion in genomic research and sequenced genomes. With the build up to sequencing larger chordate genomes it became very clear that manually annotating the billion base pairs of sequence produced was not practical and automated annotation systems were required. Several large organisations have helped address this issue, but the Ensembl project has in particular provided high-quality integrated annotation on vertebrate genomes within a consistent and open source infrastructure.
The first six articles published in the journals BMC Bioinformatics and BMC Genomics, co-ordinated by Paul Flicek at Ensembl and the European Bioinformatics Institute, reveal in detail how many of the comparative genomics, variation and regulatory data resources have been constructed.
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