There is growing evidence that proteostatic defi ciencies in neurodegenerative disease and other
diseases of protein conformation that interfere with protein stability and function can be suppressed by enhancing the activities of chaperones and restoring the proteasome and autophagy. Whether achieved by genetic approaches or small molecules, it may now be possible to achieve the goal of enhancing the concentration, conformation, quaternary structure and/or the location of a protein by readapting the innate biology of the cell to ameliorate the most challenging diseases of our era.
Event Date : 9 May 2011
Event Location: Array
Event Website: Array
