Karger Publishers has announced the release of the latest edition of the International System for Human Cytogenomic Nomenclature (ISCN 2024). Published every four years, the ISCN guide is an essential resource for human cytogeneticists, molecular geneticists, clinical geneticists, technicians, and students, offering standardized nomenclature for the interpretation and communication of human cytogenomic data.
The ISCN Standing Committee, composed of internationally recognized experts, has introduced several improvements to this edition to enhance usability and accuracy in everyday practice. Key updates include:
• Streamlined Nomenclature for genomic mapping to improve clarity and application across different technologies.
• A new introductory chapter summarizing generic rules applicable to all techniques.
• Numbered nomenclature examples to maintain consistency and facilitate quick reference across various methodologies.
Additionally, the RSA (Regional, Specific, and Aneuploidy) chapter has been expanded to cover:
• Targeted chromosome analysis
• Targeted microarray analysis
• Fusion genes
• Expansion repeats
• Methylation assays for imprinting disorders
Buyers of the ISCN 2024 will benefit from four years of free access to the online version, which includes live updates, a nomenclature search tool, access to previous ISCN editions, and supplemental resources. The online platform also features a community forum for users to connect and engage with ISCN authors and peers. Any corrections or updates will be published in the Karger journal Cytogenetic and Genome Research.
ISCN 2024 continues to be an indispensable tool, ensuring consistency and precision in the rapidly evolving field of human cytogenomics.
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