Elsevier, together with Boehringer Ingelheim, Eli Lilly and Company, Pierre Fabre, Sanofi, Servier and others, has further refined and extended its drug-drug interaction risk calculator (DDIRC) within PharmaPendium. The DDIRC 2.0 seeks to help scientists improve patient safety and effectively manage drug-drug interaction (DDI) risks across the drug development process.
Currently, DDIs account for 3-5 percent of all reported adverse drug reactions in hospitals, and this is only growing as patients today are being prescribed more drugs. The DDIRC helps drug developers predict DDIs with greater confidence and make more informed drug safety decisions, much earlier in the drug development process. The 2.0 release has advanced in-product visualization and filters supporting the quick identification of DDI risk. These visualizations are built upon a more comprehensive dataset for more reliable results. The updated tool also improves the ease of submitting dossiers to the FDA and other international medicines agencies.
The DDIRC provides calculations and predictions in a transparent, explainable way, removing the black box around equations using mechanistic static modeling, replicating the physiological processes occurring in the body. The tool enables researchers to track predictions through the development cycle from pre-clinical to phase 3 trials and project manage multiple simulations at the same time. It also assists with inclusion and exclusion criteria for patients in phase 2 and 3 trials to improve safety.
The predictive power of PharmaPendium’s DDIRC enables researchers to compare their valuable internal data with external data including public regulatory filings to understand the extent of drug reactions. The DDIRC has been developed in line with the FDA’s guidelines for prediction of enzyme-mediated DDI risk to make dossier submissions as straightforward as possible. PharmaPendium’s DDIRC 2.0 is now available.
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