STM publisher Elsevier has announced that UCL has subscribed to PharmaPendium, part of Elsevier's R&D Solutions for Pharma and Life Sciences. PharmaPendium is a decision support solution designed to help improve drug development decisions by enabling access to the most comprehensive resource of fully searchable FDA/EMA drug approval documents and associated comparative extracted databases. PharmaPendium is now available to students and researchers in UCL's recently created Clinical Pharmacology and Therapeutics group.
UCL selected PharmaPendium to support the work of students and the projects of various research groups, including research into drug repurposing and personalized treatments. Researchers at UCL will use PharmaPendium to evaluate dosing regimens and explore the potential for optimizing the efficacy-safety profile of currently approved medicines.
UCL Clinical Pharmacology and Therapeutics aims to uncover safer dosing strategies to repurpose existing medicines for particular population sub-groups and phenotypes, such as seniors over 80, as well as pediatric and oncology patients. Currently, drug approvals are made based on the benefit to the maximum number of patients suffering a disease. As a result of advances in the understanding of the determinants of drug response and variability along with the possibility of genetic profiling and screening, researchers now have the potential to target smaller patient sub-groups and suggest individualised dosing regimens that will deliver the improved outcomes for individual patients in those specific sub-groups. The availability of PharmaPendium will enable UCL researchers to gain a thorough, historical insight into the efficacy, safety and pharmacokinetics of specific compounds and existing medicines. This helps their researchers to better identify benchmarks and establish the clinical relevance for further evaluation of personalised treatments supported by safe dosing regimens.
PharmaPendium provides insights and information on critical areas of drug development including drug safety, ADME and drug-drug interactions which help researchers make better, more informed decisions. It delivers content from fully searchable FDA and EMA drug approval documents; FDA AERS; FDA advisory committee meetings and selected journals. Furthermore, its extracted databases, excerpted from drug approval documents, provide exportable data on drug safety, pharmacokinetics and metabolizing enzymes and transporters, and essential information across preclinical, clinical and post-market stages, that is needed to help reduce risks and support the drug approval process.
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