SSCI, a division of AMRI, has announced the publication of 'Taxonomy of Cocrystal Ternary Phase Diagrams' in the Journal of Chemical & Engineering Data, authored by Richard B. McClurg, research fellow at SSCI.
The publication follows the Lunch and Learn series hosted by SSCI in November and December 2016 that brought together more than 100 industry scientific experts and intellectual property leaders to discuss the implications of the latest FDA guidance on pharmaceutical cocrystals as drug substances.
The report establishes the value of using free energy surfaces as the basis of a classification system for cocrystal ternary phase diagrams. The three components in each diagram are the active pharmaceutical ingredient (API), coformer, and solvent. In addition to topologically distinct diagrams, phase diagrams are distinguished as to the congruent or incongruent dissolution of the cocrystalline phase. The diagrams are organised according to the set of solid phases and the number of three-phase regions. Phase diagrams and free energy surfaces are provided for representative examples of each illustrated case.
The publication is available in print (Richard B. McClurg, J. Chem. Eng. Data, 61(12), 4313–4320.) and on the ACS website, http://pubs.acs.org/journal/jceaax.
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